Cyth4 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and intercellular bridge. Is expressed in brain. Orthologous to human CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyth4 |
| Official Name | cytohesin 4 [Source:MGI Symbol;Acc:MGI:2441702] |
| Ensembl ID | ENSMUSG00000018008 |
| Bio databases IDs | |
| Aliases | cytohesin 4 |
| Synonyms | 2510004M07Rik, 5830469K17Rik, CYT4, cytohesin-4, DJ63G5.1, mFLJ00017, PSCD4, RGD1564842 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyth4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- juvenile rheumatoid arthritis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- centrosome
- cytoplasmic bridges
- cytosol
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyth4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- centriolar satellite
- cytosol
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding