Inava Gene Summary [Mouse]
Involved in adherens junction maintenance; intestinal epithelial structure maintenance; and positive regulation of protein ubiquitination. Predicted to be located in cytoplasm and nuclear body. Is expressed in gut; metanephros; olfactory epithelium; respiratory system; and submandibular gland primordium. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Inava |
| Official Name | innate immunity activator [Source:MGI Symbol;Acc:MGI:1921579] |
| Ensembl ID | ENSMUSG00000041605 |
| Bio databases IDs | |
| Aliases | innate immunity activator |
| Synonyms | 1700034M08Rik, 4933426C09Rik, 5730559C18Rik, C1orf106, D1Mgi54, innate immunity activator, RGD1311892 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inava often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytohesin Ubiquitin Protein Inducing Domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- multiple sclerosis
- ankylosing spondylitis
- ulcerative colitis
- colitis
- schizophrenia
- anterior uveitis
- inflammatory bowel disease type 29
- male pattern hair loss
- Crohn disease
regulated by
- clopidogrel
- SOX2
role in cell
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inava gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to peptidoglycan
- response to muramyl dipeptide
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of MAPK cascade
- pattern recognition receptor signaling pathway
- positive regulation of cytokine production involved in immune response
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- innate immune response
- intestinal epithelial structure maintenance
- positive regulation of protein ubiquitination
- adherens junction maintenance
- positive regulation of interleukin-6 production
- positive regulation of interleukin-10 production
- positive regulation of stress-activated MAPK cascade
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding