Pip4k2b Gene Summary [Mouse]
Predicted to enable phosphatidylinositol kinase activity; protein homodimerization activity; and purine ribonucleoside triphosphate binding activity. Involved in autophagosome-lysosome fusion and regulation of autophagy. Acts upstream of or within phosphatidylinositol metabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in head bone; nervous system; and sensory organ. Orthologous to human PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pip4k2b |
| Official Name | phosphatidylinositol-5-phosphate 4-kinase, type II, beta [Source:MGI Symbol;Acc:MGI:1934234] |
| Ensembl ID | ENSMUSG00000018547 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-5-phosphate 4-kinase, type II, beta |
| Synonyms | c11, phosphatidylinositol-5-phosphate 4-kinase type 2 beta, phosphatidylinositol-5-phosphate 4-kinase type 2 β, phosphatidylinositol-5-phosphate 4-kinase, type II, beta, phosphatidylinositol-5-phosphate 4-kinase, type II, β, PI5P4KB, PI5P4Kbeta, PIP4K2 beta, PIP4K2 β, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pip4k2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- GTP binding
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- activation domain
- ATP binding
- protein homodimerization
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the Pip4k2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- coronary artery disease
- myocardial infarction
- breast carcinoma
regulates
- phosphatidylinositol
- 1-phosphatidyl-D-myo-inositol 4,5-bisphosphate
- phosphtidylinositol 5-phosphate
role in cell
- proliferation
- autophagy by
- growth
- replication in
- assembly
- adaptation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pip4k2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of autophagy
- positive regulation of autophagic vacuole assembly
- phosphatidylinositol phosphorylation
- cell surface receptor signaling pathway
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- plasma membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- protein homodimerization activity
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- 1-phosphatidylinositol-5-phosphate 4-kinase activity