Sema6a Gene Summary [Mouse]
Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in generation of neurons; positive regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway and centrosome localization. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SEMA6A (semaphorin 6A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema6a |
| Official Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [Source:MGI Symbol;Acc:MGI:1203727] |
| Ensembl ID | ENSMUSG00000019647 |
| Bio databases IDs | |
| Aliases | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms | A730020P05Rik, AI851735, HT018, SEMA, SEMA6A1, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, semaphorin 6A, SEMAQ, VIA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- semaphorin receptor binding
- ectodomain
- protein binding
- identical protein binding
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema6a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ophthalmic disorder
- neoplasia
- drowsiness
- renal clear cell adenocarcinoma
- renal clear cell cancer
- cleft lip
- lung adenocarcinoma
- lung adenocarcinoma formation
- proliferative diabetic retinopathy
- idiopathic scoliosis
role in cell
- expression in
- cell death
- proliferation
- binding in
- phosphorylation in
- migration
- growth
- survival
- outgrowth
- arborization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell borders
- cellular membrane
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative chemotaxis
- cytoskeleton organization
- nervous system development
- axon guidance
- cell surface receptor signaling pathway
- organ morphogenesis
- negative regulation of vascular endothelial growth factor signaling pathway
- neural crest cell migration
- negative regulation of ERK1 and ERK2 cascade
- apoptotic process
- cellular response to vascular endothelial growth factor stimulus
- semaphorin-plexin signaling pathway
- positive regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- membrane
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding