Grm1 Gene Summary [Mouse]
Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration and G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and synaptic signaling via neuropeptide. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm1 |
| Official Name | glutamate receptor, metabotropic 1 [Source:MGI Symbol;Acc:MGI:1351338] |
| Ensembl ID | ENSMUSG00000019828 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 1 |
| Synonyms | 4930455H15Rik, glutamate metabotropic receptor 1, glutamate receptor, metabotropic 1, Gm10828, GPRC1A, Metabotropic glutamate receptor 1a, MGLU1, MGLUR1, MGLUR1A, Mglur1 alpha, Mglur1 α, Mgr1 α, nmf373, PPP1R85, rcw, SCA44, SCAR13, wobl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Receptor family ligand binding region
- intracellular loop
- 7 transmembrane sweet-taste receptor of 3 GCPR
- estrogen receptor binding
- protein binding
- proline rich domain
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- neurotransmitter receptor
- PLC activating metabotropic glutamate receptor
- ligand-binding domain
- Caveolin-1 binding domain
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Homer-binding domain of metabotropic glutamate receptor
- intracellular domain
- Nine Cysteines Domain of family 3 GPCR
- cytosolic tail domain
- PDZ binding motif
- G-protein binding domain
Pathways
Biological processes and signaling networks where the Grm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Huntington's Disease Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- global developmental delay
- spinocerebellar ataxia type 44
- prostate cancer
- schizophrenia
- ataxia
- autosomal recessive spinocerebellar ataxia type 13
- metabolic syndrome X
- tremor
role in cell
- expression in
- production in
- apoptosis
- cell death
- binding
- phosphorylation in
- activation in
- formation in
- transformation
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- cytoskeleton
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- cellular membrane
- Nucleus
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- neurites
- dendrite initial segments
- synaptosomes
- synapse
- early endosomes
- rough endoplasmatic reticulum
- microsomal membrane
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- postsynaptic terminals
- dendritic branches
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- G-protein coupled receptor signaling pathway
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- synaptic transmission
- positive regulation of MAPK cascade
- G-protein coupled glutamate receptor signaling pathway
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
- locomotory behavior
- sensory perception of pain
- cellular response to electrical stimulus
- regulation of synaptic transmission, glutamatergic
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- G-protein coupled receptor dimeric complex
- dendrite
- nucleus
- G-protein coupled receptor homodimeric complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- glutamate receptor activity
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity