Pno1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; heart; and immune system. Orthologous to human PNO1 (partner of NOB1 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pno1 |
| Official Name | partner of NOB1 homolog [Source:MGI Symbol;Acc:MGI:1913499] |
| Ensembl ID | ENSMUSG00000020116 |
| Bio databases IDs | |
| Aliases | partner of NOB1 homolog |
| Synonyms | 1810003N24RIK, Emi3, Imi3, KHRBP1, LOC56902, partner of NOB1 homolog, RRP20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pno1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH domain
- arCOG04150 universal archaeal KH domain protein
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- expression in
- apoptosis
- cell viability
- cell death
- autophagy in
- colony formation by
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pno1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding