Cirbp Gene Summary [Mouse]
Enables poly(U) RNA binding activity and translation repressor activity. Involved in stress granule assembly. Acts upstream of or within cellular response to cold; negative regulation of cell growth; and regulation of cell cycle G1/S phase transition. Located in cytoplasmic stress granule and nucleoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; and retina. Orthologous to human CIRBP (cold inducible RNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cirbp |
| Official Name | cold inducible RNA binding protein [Source:MGI Symbol;Acc:MGI:893588] |
| Ensembl ID | ENSMUSG00000045193 |
| Bio databases IDs | |
| Aliases | cold inducible RNA binding protein |
| Synonyms | A18 HNRNP, CIRP, Cold induced RNA binding, Cold-inducible RBP, cold inducible RNA binding protein, eCIRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cirbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- low complexity domain
- rRNA binding
- RNA recognition motif
- translation repressor
- protein binding
- translation regulator
- poly(U) binding protein
- RNA binding
Pathways
Biological processes and signaling networks where the Cirbp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- organismal death
- Huntington disease
- acute lung injury
- colon carcinoma
- colon epithelial cancer
- androgenic alopecia
- immunodeficiency
role in cell
- activation in
- apoptosis
- expression in
- proliferation
- growth
- phosphorylation in
- migration
- synthesis in
- colony formation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cirbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- stress granule assembly
- positive regulation of translation
- positive regulation of nuclear mRNA splicing, via spliceosome
- mRNA stabilization
- response to UV
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation repressor activity
- SSU rRNA binding
- mRNA 3'-UTR binding