Dok3 Gene Summary [Mouse]
Acts upstream of or within Ras protein signal transduction. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human DOK3 (docking protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dok3 |
| Official Name | docking protein 3 [Source:MGI Symbol;Acc:MGI:1351490] |
| Ensembl ID | ENSMUSG00000035711 |
| Bio databases IDs | |
| Aliases | docking protein 3 |
| Synonyms | docking protein 3, DOKL, FLJ22570 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dok3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- PH domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Dok3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- lung cancer
- tumorigenesis
- coronary artery disease
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
- non-small cell lung cancer
- lung carcinoma process
role in cell
- signaling in
- activation
- development
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dok3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding