Tpgs1 Gene Summary [Mouse]
Enables microtubule binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including adult behavior; protein polyglutamylation; and sperm axoneme assembly. Predicted to be located in centrosome and membrane. Predicted to be active in microtubule organizing center. Orthologous to human TPGS1 (tubulin polyglutamylase complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpgs1 |
| Official Name | tubulin polyglutamylase complex subunit 1 [Source:MGI Symbol;Acc:MGI:106618] |
| Ensembl ID | ENSMUSG00000020308 |
| Bio databases IDs | |
| Aliases | tubulin polyglutamylase complex subunit 1 |
| Synonyms | C19orf20, D14MGI8, Gm16517, GTRGEO22, LOC687166, PGs1, Rosa22, tubulin polyglutamylase complex subunit 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpgs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- acid-D-amino acid ligase
- tubulin binding
- enzyme
- protein binding
- DD_R_PKA_DPY30-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- cilia
- cellular membrane
- centrosome
- centriole
- cytosol
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpgs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglutamylation
- synaptic transmission
- vesicle localization
- sperm axoneme assembly
- adult behavior
Cellular Component
Where in the cell the gene product is active
- dendrite
- centrosome
- motile cilium
- cytoplasm
- centriolar satellite
- synapse
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin-glutamic acid ligase activity
- microtubule binding