Rufy3 Gene Summary [Mouse]
Involved in several processes, including positive regulation of axon extension; positive regulation of intracellular protein transport; and regulation of establishment of cell polarity. Acts upstream of or within positive regulation of axonogenesis. Located in growth cone and perikaryon. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human RUFY3 (RUN and FYVE domain containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rufy3 |
| Official Name | RUN and FYVE domain containing 3 [Source:MGI Symbol;Acc:MGI:106484] |
| Ensembl ID | ENSMUSG00000029291 |
| Bio databases IDs | |
| Aliases | RUN and FYVE domain containing 3 |
| Synonyms | 2810428M05Rik, 6330416M07Rik, D5Bwg0860e, RIPX, Rpipx, RUN and FYVE domain containing 3, SINGAR1, ZFYVE30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rufy3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein of unknown function (DUF3729)
- cytoskeletal protein binding
- domain involved in Ras-like GTPase signaling
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- SWI5-dependent HO expression protein 3
- protein binding
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- growth cone
- endolysosomes
- filopodia
- perikaryon
- axons
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rufy3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- negative regulation of axonogenesis
- regulation of axonogenesis
- nervous system development
- cell differentiation
- actin filament organization
- positive regulation of axon extension
- regulation of establishment of cell polarity
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- perikaryon
- growth cone
- dendrite
- anchoring junction
- cytoplasm
- membrane
- filopodium
- endomembrane system
- cytosol
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding