Patz1 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in negative regulation of endothelial cell migration. Acts upstream of or within several processes, including T cell differentiation; male gonad development; and positive regulation of DNA-templated transcription. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb bud; nervous system; and sensory organ. Orthologous to human PATZ1 (POZ/BTB and AT hook containing zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Patz1 |
| Official Name | POZ (BTB) and AT hook containing zinc finger 1 [Source:MGI Symbol;Acc:MGI:1891832] |
| Ensembl ID | ENSMUSG00000020453 |
| Bio databases IDs | |
| Aliases | POZ (BTB) and AT hook containing zinc finger 1 |
| Synonyms | 8430401L15Rik, dJ400N23, MAZR, PATZ, POZ (BTB) and AT hook containing zinc finger 1, POZ/BTB and AT hook containing zinc finger 1, RIAZ, ZBTB19, ZFP278, ZNF278, ZSG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Patz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- ubiquitin protein ligase binding
- transcription regulator
- nucleic acid binding
- BTB_POZ
- Putative zinc-finger between two C2H2 zinc-fingers on Patz
- chromatin binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- zinc finger
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- exencephaly
- colorectal adenoma
- colorectal adenoma formation
- growth failure
- transposition of great vessel
- azoospermia
regulates
- Tpsb2
- KLK3
role in cell
- proliferation
- number
- differentiation
- cell cycle progression
- migration by
- cellular subpopulation ratio
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Patz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- T cell differentiation
- male gonad development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- spermatogenesis
- regulation of transcription, DNA-dependent
- regulation of cytokine production
- regulation of immune system process
- negative regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding