Polm Gene Summary [Mouse]
Predicted to enable DNA-directed DNA polymerase activity. Acts upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be active in nucleus. Is expressed in muscle tissue and retina. Orthologous to human POLM (DNA polymerase mu). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polm |
| Official Name | polymerase (DNA directed), mu [Source:MGI Symbol;Acc:MGI:1860191] |
| Ensembl ID | ENSMUSG00000020474 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), mu |
| Synonyms | B230309I03RIK, DNA POLYMERASE MU, LOC100132763, Pol Mu, polymerase (DNA directed), mu, Pol-ι, Tdt-N |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- PCNA binding domain
- BRCT
- DNA polymerase beta thumb
- DNA-directed DNA polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Fingers domain of DNA polymerase lambda
- BRCA1 C Terminus (BRCT) domain
- DNA polymerase X family
- enzyme
- protein binding
- DNA polymerase beta palm
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA biosynthetic process
- DNA recombination
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding