Rassf5 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of lymphocyte proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Located in nucleus. Is expressed in heart and thymus primordium. Used to study systemic lupus erythematosus. Orthologous to human RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rassf5 |
| Official Name | Ras association (RalGDS/AF-6) domain family member 5 [Source:MGI Symbol;Acc:MGI:1926375] |
| Ensembl ID | ENSMUSG00000026430 |
| Bio databases IDs | |
| Aliases | Ras association (RalGDS/AF-6) domain family member 5 |
| Synonyms | 1300019G20Rik, AU042887, MAXP1, NORE1, Nore1A, NORE1B, RAPL, Ras association domain family member 5, Ras association (RalGDS/AF-6) domain family member 5, RASSF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rassf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- central domain
- coiled-coil domain
- protein binding
- proline rich domain
- identical protein binding
- SARAH_SF
- SARAH domain
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- Ubl1_cv_Nsp3_N-like
- Ras/Rap binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Ras-binding domain
- zinc finger domain
- MST1/2 binding domain
Pathways
Biological processes and signaling networks where the Rassf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung carcinoma process
- lung cancer
- epithelial cancer
- thoracic cancer
- epithelial neoplasia
- cancer
- hypoplasia
- colorectal cancer
- abdominal cancer
role in cell
- apoptosis
- cell death
- growth
- binding in
- expression in
- dephosphorylation in
- phosphorylation in
- proliferation
- activation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- Nucleus
- vesicles
- centrosome
- Mitochondria
- microtubules
- microtubule organizing centers
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rassf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of lymphocyte proliferation
- lymphocyte proliferation
- signal transduction
- apoptotic process
- positive regulation of protein ubiquitination
- regulation of protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding