Paip2 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within several processes, including memory; negative regulation of translation; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in embryo and retina. Orthologous to human PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Paip2 |
| Official Name | polyadenylate-binding protein-interacting protein 2 [Source:MGI Symbol;Acc:MGI:1915119] |
| Ensembl ID | ENSMUSG00000037058 |
| Bio databases IDs | |
| Aliases | polyadenylate-binding protein-interacting protein 2 |
| Synonyms | 2310050K10Rik, PAIP2A, poly(A) binding protein interacting protein 2, polyadenylate-binding protein-interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Paip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- translation repressor
- Ataxin-2 C-terminal region
- nucleic acid binding translation repressor
- poly(A) binding protein
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Paip2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- azoospermia
role in cell
- expression in
- formation
- number
- abnormal morphology
- translation in
- maturation
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Paip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- regulation of long-term synaptic potentiation
- spermatogenesis
- negative regulation of translation
- memory
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- translation repressor activity, nucleic acid binding
- mRNA binding