Ppp1r11 Gene Summary [Mouse]

Enables protein phosphatase inhibitor activity. Involved in defense response to Gram-positive bacterium; negative regulation of cytokine production; and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; integumental system; and male reproductive gland or organ. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ppp1r11
Official Name
protein phosphatase 1, regulatory inhibitor subunit 11 [Source:MGI Symbol;Acc:MGI:1923747]
Ensembl ID
ENSMUSG00000036398
Bio databases IDs NCBI: 76497 Ensembl: ENSMUSG00000036398
Aliases protein phosphatase 1, regulatory inhibitor subunit 11
Synonyms 1500041B02Rik, AV117883, CFAP255, HCG-V, INH-3, IPP3, protein phosphatase 1 regulatory inhibitor subunit 11, protein phosphatase 1, regulatory (inhibitor) subunit 11, protein phosphatase 1, regulatory inhibitor subunit 11, TCTE5, TCTEX5
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Protein phosphatase inhibitor
  • protein phosphatase inhibitor activity
  • ubiquitin protein ligase activity
  • enzyme
  • protein binding
  • phosphatase binding

Pathways

Biological processes and signaling networks where the Ppp1r11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cutaneous melanoma
  • cutaneous melanoma cancer
regulated by
  • actinomycin D
  • SPOP
  • Influenza A virus (A/Japan/305/57(H2N2))
  • CASP3
  • hepatitis B virus
regulates
  • Pp1
  • cytokine
role in cell
  • apoptosis
  • survival

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r11 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of cytokine production
  • defense response to Gram-positive bacterium
  • ubiquitin-dependent protein catabolic process
  • protein ubiquitination

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • phosphatase binding
  • protein serine/threonine phosphatase inhibitor activity
  • protein phosphatase inhibitor activity
  • protein binding
  • protein phosphatase 1 binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.