Sh3yl1 Gene Summary [Mouse]
Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Acts upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sh3yl1 |
| Official Name | Sh3 domain YSC-like 1 [Source:MGI Symbol;Acc:MGI:1346118] |
| Ensembl ID | ENSMUSG00000020669 |
| Bio databases IDs | |
| Aliases | Sh3 domain YSC-like 1 |
| Synonyms | RAY, SH3 and SYLF domain containing 1, Sh3 domain YSC-like 1, Sh3yl1 predicted, YSC84 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3yl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Las17-binding protein actin regulator
- protein binding
- The SYLF domain (also called DUF500), a novel lipid-binding module
- phosphatidylinositol binding
- phosphatase binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3yl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ruffle assembly
- phosphatidylinositol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- phosphatidylinositol binding