Errfi1 Gene Summary [Mouse]
Predicted to enable SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including lung development; negative regulation of epidermal growth factor-activated receptor activity; and skin morphogenesis. Acts upstream of or within several processes, including intracellular signal transduction; regulation of protein kinase activity; and steroid metabolic process. Located in cytoplasm and plasma membrane. Is expressed in alveolar system; lung; and lung epithelium. Used to study endometrial cancer and osteoarthritis. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Errfi1 |
| Official Name | ERBB receptor feedback inhibitor 1 [Source:MGI Symbol;Acc:MGI:1921405] |
| Ensembl ID | ENSMUSG00000028967 |
| Bio databases IDs | |
| Aliases | ERBB receptor feedback inhibitor 1 |
| Synonyms | 1300002F13RIK, CTA-215D11.2, ERBB receptor feedback inhibitor 1, G33, GENE-33, MIG-6, RALT, RGD1307599, Xxx |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Errfi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein kinase binding
- GTPase binding
- enzyme binding
- GTPase activator
- protein binding
- EGFR receptor inhibitor Mig-6
- Ack homology domain
- SH3-domain binding
Pathways
Biological processes and signaling networks where the Errfi1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- non-insulin-dependent diabetes mellitus
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- papillomatosis
- endometrial cancer
role in cell
- apoptosis
- activation in
- growth
- expression in
- quantity
- number
- differentiation
- phosphorylation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Errfi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- epidermal growth factor receptor signaling pathway
- response to progesterone stimulus
- cholesterol metabolic process
- lung vasculature development
- lung epithelium development
- response to xenobiotic stimulus
- glucose metabolic process
- skin morphogenesis
- negative regulation of epidermal growth factor receptor signaling pathway
- cholesterol homeostasis
- lung alveolus development
- protein kinase B signaling cascade
- epithelial cell proliferation
- response to insulin stimulus
- liver development
- apoptotic process
- cell migration
- negative regulation of protein autophosphorylation
- regulation of keratinocyte differentiation
- limb joint morphogenesis
- fat pad development
- bile acid biosynthetic process
- embryo implantation
- tissue homeostasis
- progesterone receptor signaling pathway
- response to estradiol stimulus
- chondrocyte proliferation
- gene expression
- uterine epithelium development
- protein localization in plasma membrane
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- GTPase activator activity