Pccb Gene Summary [Mouse]
Predicted to enable propionyl-CoA carboxylase activity. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and respiratory system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCB (propionyl-CoA carboxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pccb |
| Official Name | propionyl Coenzyme A carboxylase, beta polypeptide [Source:MGI Symbol;Acc:MGI:1914154] |
| Ensembl ID | ENSMUSG00000032527 |
| Bio databases IDs | |
| Aliases | propionyl Coenzyme A carboxylase, beta polypeptide |
| Synonyms | 1300012P06Rik, betaPCC, Ppcb, Propionyl-CoA Carboxylase beta, propionyl-CoA carboxylase subunit beta, propionyl-CoA carboxylase subunit β, Propionyl-CoA Carboxylase β, propionyl Coenzyme A carboxylase, beta polypeptide, propionyl Coenzyme A carboxylase, β polypeptide, βPCC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pccb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- propionyl-CoA carboxylase
- enzyme
- protein binding
- methylmalonyl-CoA decarboxylase alpha subunit
- Carboxyl transferase domain
Pathways
Biological processes and signaling networks where the Pccb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- propionic acidemia
- hereditary disorder
- neuroticism
- metabolic syndrome X
- myocardial infarction
- venous thromboembolism
- coronary artery disease
- early onset hypertension
regulates
- fatty acid
- amino acids
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pccb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- short-chain fatty acid catabolic process
- branched chain family amino acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- propionyl-CoA carboxylase activity
- protein binding