Asic2 Gene Summary [Mouse]
Enables monoatomic ion-gated channel activity and pH-gated sodium channel activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine; neuronal cell body; and plasma membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asic2 |
| Official Name | acid-sensing (proton-gated) ion channel 2 [Source:MGI Symbol;Acc:MGI:1100867] |
| Ensembl ID | ENSMUSG00000020704 |
| Bio databases IDs | |
| Aliases | acid-sensing (proton-gated) ion channel 2 |
| Synonyms | ACCN, ACCN1, ACIC2, acid-sensing ion channel 2, acid sensing ion channel subunit 2, ASIC2a, BNaC1, BNaC1a, BNC1, BNC1k, degenerin, hBNaC1, MDEG, MDEG1, MDEG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asic2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated sodium channel
- channel/pore class transporter
- amiloride-sensitive sodium channel
- sodium channel transporter
- ligand-gated ion channel
- protein binding
- pore domain
- ion channel
- cation channel
- degenerin
Pathways
Biological processes and signaling networks where the Asic2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- seizures
- heart failure
- COVID-19
- hypertension
- proteinuria
- pneumonia
- acute myeloid leukemia
- major depression
- essential hypertension
role in cell
- apoptosis
- growth
- transmembrane potential
- assembly
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- reticular fibers
- cellular membrane
- synaptic membrane
- dendritic spines
- neurites
- nerve ending
- synapse
- perikaryon
- dendrites
- penicillate terminals
- palisade terminals
- dendritic branches
- axon branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asic2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sour taste
- peripheral nervous system development
- synaptic transmission
- phototransduction
- regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
- sensory perception of sound
- synapse assembly
- regulation of membrane potential
- central nervous system development
- negative regulation of apoptotic process
- cellular response to acidity
- regulation of ion transmembrane transport
- sodium ion transmembrane transport
- cellular response to xenobiotic stimulus
- establishment of localization in cell
- protein localization to synapse
- positive regulation of synapse assembly
- regulation of vasoconstriction
- detection of mechanical stimulus involved in sensory perception
Cellular Component
Where in the cell the gene product is active
- dendritic spine
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ion gated channel activity
- protein binding
- ligand-gated sodium channel activity
- voltage-gated sodium channel activity