Rnf135 Gene Summary [Mouse]
Predicted to enable several functions, including RIG-I binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in RIG-I signaling pathway; antiviral innate immune response; and protein polyubiquitination. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; heart; and testis. Orthologous to human RNF135 (ring finger protein 135). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf135 |
| Official Name | ring finger protein 135 [Source:MGI Symbol;Acc:MGI:1919206] |
| Ensembl ID | ENSMUSG00000020707 |
| Bio databases IDs | |
| Aliases | ring finger protein 135 |
| Synonyms | 0610037N03Rik, 2410006N06RIK, L13, LRRGT00184, MMFD, REUL, ring finger protein 135, Riplet, U 2-3-0 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf135 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- receptor binding
- identical protein binding
- associated with SPRY domains
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- ribonucleoprotein binding
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf135 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interferon-beta production
- protein polyubiquitination
- innate immune response
- regulation of innate immune response
- protein homooligomerization
- RIG-I signaling pathway
- protein K63-linked ubiquitination
- free ubiquitin chain polymerization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- metal ion binding
- RIG-I binding
- ribonucleoprotein complex binding