Cacna1g Gene Summary [Mouse]
Enables low voltage-gated calcium channel activity. Acts upstream of or within several processes, including regulation of atrial cardiac muscle cell membrane depolarization; regulation of heart rate; and response to nickel cation. Located in plasma membrane. Is expressed in central nervous system; heart; hindlimb musculature; lower jaw molar; and retina. Used to study cerebellar ataxia type 42. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42. Orthologous to human CACNA1G (calcium voltage-gated channel subunit alpha1 G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1g |
| Official Name | calcium channel, voltage-dependent, T type, alpha 1G subunit [Source:MGI Symbol;Acc:MGI:1201678] |
| Ensembl ID | ENSMUSG00000020866 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, T type, alpha 1G subunit |
| Synonyms | a1G, [a]1G, alpha-1G, Calcium Channel alpha1g, calcium channel, voltage-dependent, T type, alpha 1G subunit, calcium channel, voltage-dependent, T type, α 1G subunit, Calcium Channel α 1G, calcium voltage-gated channel subunit alpha1 G, CaV3.1, Cav3.1d, Ca(V)T.1, mKIAA1123, NBR13, SCA42, SCA42ND, α-1G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacna1g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Ion transport protein
- low voltage-gated calcium channel
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Cacna1g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bradycardia
- hypogonadotropic hypogonadism
- schizophrenia
- hereditary spastic ataxia
- Alzheimer disease
- partial seizure without secondary generalization
- partial seizure
- early-onset severe spinocerebellar ataxia-42 with neurodevelopmental deficits
- spinocerebellar ataxia type 42
- schizoaffective disorder
regulates
- Ca2+
- adenosine triphosphate
role in cell
- cell death
- number
- proliferation
- transport in
- action potential
- transmembrane potential
- activity
- excitability
- migration by
- action potential by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- dendrite initial segments
- Z line
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacna1g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane depolarization involved in regulation of SA node cardiac muscle cell action potential
- regulation of cardiac muscle cell action potential involved in contraction
- calcium ion import
- membrane depolarization involved in regulation of AV node cardiac muscle cell action potential
- SA node cardiomyocyte to atrial cardiomyocyte signalling
- regulation of atrial cardiomyocyte membrane depolarization
- regulation of SA node cardiac muscle cell action potential
- regulation of AV node cardiac muscle cell action potential
- AV node to bundle of His cell signaling
- synaptic transmission
- sinoatrial node development
- regulation of membrane potential
- calcium ion transmembrane transport
- regulation of heart rate by cardiac conduction
- response to nickel cation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- voltage-gated calcium channel complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- voltage-gated calcium channel activity involved in regulation of AV node cardiac muscle cell action potential
- high voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in regulation of SA node cardiac muscle cell action potential
- low voltage-gated calcium channel activity