GTF2A1 Gene Summary [Human]
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | GTF2A1 |
| Official Name | general transcription factor IIA subunit 1 [Source:HGNC Symbol;Acc:HGNC:4646] |
| Ensembl ID | ENSG00000165417 |
| Bio databases IDs | |
| Aliases | general transcription factor IIA subunit 1, TFIIA alpha/beta subunits |
| Synonyms | 6330549H03RIK, general transcription factor 2A subunit 1, general transcription factor II A, 1, general transcription factor IIA subunit 1, Tf2a, TF2A1, TFIIA, Tfiia1, TFIIA-42, TfIIAa/b, TFIIA alpha/beta, TFIIAL, TFIIA α/β, TFIIA β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF2A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor IIA, alpha/beta subunit
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- sequence-specific DNA binding
- TATA-binding protein binding
- protein heterodimerization
- DNA binding
Pathways
Biological processes and signaling networks where the GTF2A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF2A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- cytosol
- transcription factor TFIIA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- general RNA polymerase II transcription factor activity
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding