Rtn1 Gene Summary [Mouse]
Predicted to be involved in endoplasmic reticulum tubular network formation; negative regulation of amyloid-beta formation; and nervous system development. Located in dendrite; endoplasmic reticulum; and neuronal cell body. Is expressed in several structures, including genitourinary system; immune system; nervous system; neural retina; and skin. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rtn1 |
| Official Name | reticulon 1 [Source:MGI Symbol;Acc:MGI:1933947] |
| Ensembl ID | ENSMUSG00000021087 |
| Bio databases IDs | |
| Aliases | reticulon 1 |
| Synonyms | 4930441F12RIK, NSP, reticulon 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- lumenal/extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- schizophrenia
- colorectal cancer
- myopia
- Parkinson disease
- major depression
- insomnia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- multicentric carpotarsal osteolysis syndrome
role in cell
- growth
- apoptosis
- formation
- formation in
- flux in
- distribution in
- endoplasmic reticulum stress response
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- endoplasmic reticulum mitochondria contact site
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear bodies
- nuclear envelope
- growth cone
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- endoplasmic reticulum tubular network assembly
- brain development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- dendrite
- endoplasmic reticulum
- Golgi membrane
- neuronal cell body
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding