RTN1 Gene Summary [Human]
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Details
| Type | Retained Intron |
| Official Symbol | RTN1 |
| Official Name | reticulon 1 [Source:HGNC Symbol;Acc:HGNC:10467] |
| Ensembl ID | ENSG00000139970 |
| Bio databases IDs | |
| Aliases | reticulon 1 |
| Synonyms | 4930441F12RIK, NSP, reticulon 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- lumenal/extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- schizophrenia
- colorectal cancer
- myopia
- Parkinson disease
- major depression
- insomnia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- multicentric carpotarsal osteolysis syndrome
role in cell
- growth
- apoptosis
- formation
- formation in
- flux in
- distribution in
- endoplasmic reticulum stress response
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- endoplasmic reticulum mitochondria contact site
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear bodies
- nuclear envelope
- growth cone
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- endoplasmic reticulum tubular network assembly
- brain development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- dendrite
- endoplasmic reticulum
- Golgi membrane
- neuronal cell body
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding