Lgmn Gene Summary [Mouse]
This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Lgmn |
| Official Name | legumain [Source:MGI Symbol;Acc:MGI:1330838] |
| Ensembl ID | ENSMUSG00000021190 |
| Bio databases IDs | |
| Aliases | legumain |
| Synonyms | AEP, Asn Endopeptidase, Asparaginyl Endopeptidase, legumain, LGMN1, PRSC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgmn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CASc
- cysteine endopeptidase
- peptidase
- protein binding
- enzyme regulator activity
- protease activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- tubulo-interstitial fibrosis
- weight gain
- diabetes mellitus
- hydronephrosis
- metastasis
- organismal death
- proteinuria
- multicentric carpotarsal osteolysis syndrome
- fibrosis
role in cell
- expression in
- molecular cleavage in
- apoptosis
- activation in
- downregulation in
- migration
- accumulation in
- proliferation
- loss
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cell cortex
- endosomes
- vesicles
- lysosome
- lysosomal compartment
- perinuclear space
- late endosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgmn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- positive regulation of long-term synaptic potentiation
- positive regulation of cell proliferation
- associative learning
- memory
- renal system process
- negative regulation of neuron apoptotic process
- vitamin D metabolic process
- self proteolysis
- receptor catabolic process
- cellular response to calcium ion
- activation of cysteine-type endopeptidase activity
- positive regulation of endothelial cell chemotaxis
- protein maturation
- proteolysis involved in cellular protein catabolic process
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of monocyte chemotaxis
- dendritic spine organization
- positive regulation of mitotic cell cycle
- negative regulation of gene expression
- vacuolar protein processing
- cellular response to hepatocyte growth factor stimulus
- proteolysis
- response to acidity
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- apical part of cell
- cytoplasm
- endolysosome lumen
- late endosome
- lysosomal lumen
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- tau protein binding
- cysteine-type endopeptidase activity
- peptidase activity