Hecw1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; sensory organ; and testis. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hecw1 |
| Official Name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2444115] |
| Ensembl ID | ENSMUSG00000021301 |
| Bio databases IDs | |
| Aliases | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms | 9330116H24Rik, BUL1, E130207I19Rik, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1, KIAA0322, LOC102724911, LOC103694104, NEDL1, RGD1561038 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hecw1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- Domain with 2 conserved Trp (W) residues
- Helical box domain of E3 ubiquitin-protein ligase HECW1
- N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
- ubiquitin protein ligase activity
- WW
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
- Protein kinase C conserved region 2 (CalB)
- WW domain
- C2 domain
Pathways
Biological processes and signaling networks where the Hecw1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- esophageal adenocarcinoma
- esophageal carcinoma formation
- organismal death
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- survival
- insulin-dependent diabetes mellitus
- thyroid cancer
- Alzheimer disease
role in cell
- proliferation
- migration
- degradation in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hecw1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of sodium ion transmembrane transporter activity
- regulation of dendrite morphogenesis
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding