Tnfaip8l2 Gene Summary [Mouse]
Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfaip8l2 |
| Official Name | tumor necrosis factor, alpha-induced protein 8-like 2 [Source:MGI Symbol;Acc:MGI:1917019] |
| Ensembl ID | ENSMUSG00000013707 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor, alpha-induced protein 8-like 2 |
| Synonyms | 1810019A08Rik, RGD1310519, TIPE2, TNF alpha induced protein 8 like 2, TNF α induced protein 8 like 2, tumor necrosis factor, alpha-induced protein 8-like 2, tumor necrosis factor, α-induced protein 8-like 2, tumour necrosis factor, alpha-induced protein 8-like 2, tumour necrosis factor, α-induced protein 8-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfaip8l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF758)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- hyperplasia
- tumorigenesis
- cutaneous melanoma
- cholangiocarcinoma cancer
- head and neck squamous cell carcinoma
- hepatocellular carcinoma
- papillary renal cell carcinoma
- renal clear cell adenocarcinoma
- mucinous ovarian carcinoma
role in cell
- cell death
- number
- expression in
- growth
- production in
- proliferation
- activation in
- apoptosis
- phosphorylation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfaip8l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- negative regulation of inflammatory response
- T cell activation
- regulation of apoptotic process
- negative regulation of T cell activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding