Elovl2 Gene Summary [Mouse]
Enables fatty acid elongase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within very long-chain fatty acid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; liver; paravertebral ganglion; sensory organ; and urinary system. Orthologous to human ELOVL2 (ELOVL fatty acid elongase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elovl2 |
| Official Name | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 [Source:MGI Symbol;Acc:MGI:1858960] |
| Ensembl ID | ENSMUSG00000021364 |
| Bio databases IDs | |
| Aliases | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 |
| Synonyms | Elo2, Elovl2 (predicted), ELOVL fatty acid elongase 2, Fatty acid elongase 2, LOC682492, SSC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elovl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GNS1/SUR4 family
- fatty acid elongase
- enzyme
- protein binding
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- side effect
- diabetes mellitus
- coronary artery disease
- hepatic steatosis
- weight gain
role in cell
- expression in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elovl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- linoleic acid metabolic process
- long-chain fatty-acyl-CoA biosynthetic process
- alpha-linolenic acid metabolic process
- very long-chain fatty acid biosynthetic process
- fatty acid elongation, saturated fatty acid
- fatty acid elongation, polyunsaturated fatty acid
- fatty acid elongation, monounsaturated fatty acid
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty acid elongase activity