Nsun2 Gene Summary [Mouse]
Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytidine-5-)-methyltransferase activity. Involved in several processes, including RNA processing; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsun2 |
| Official Name | NOL1/NOP2/Sun domain family member 2 [Source:MGI Symbol;Acc:MGI:107252] |
| Ensembl ID | ENSMUSG00000021595 |
| Bio databases IDs | |
| Aliases | NOL1/NOP2/Sun domain family member 2 |
| Synonyms | D13Wsu123e, MISU, MRT5, NOL1/NOP2/Sun domain family member 2, NOP2/Sun RNA methyltransferase 2, RGD1311954, SAKI, TRM4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsun2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (cytosine-5-)-methyltransferase
- NOL1/NOP2/sun family putative RNA methylase
- 16S rRNA methyltransferase RsmB/F
- enzyme
- protein binding
- AdoMet_MTases
- mRNA methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- prostate cancer
- cancer
- Alzheimer disease
- recurrent cancer
- stomach and esophageal carcinoma
- esophageal carcinoma formation
- gastric epithelial cancer
- rectal adenocarcinoma
phenotypes
- developmental and structural abnormality
- hypoplasia
- process of degenerative change
- synechia
- abnormal coat appearance
- abnormal cornea morphology
- abnormal cranium morphology
- abnormal deltoid tuberosity morphology
- abnormal dorsal root ganglion morphology
- abnormal ductus venosus valve morphology
- abnormal epidermis stratum basale morphology
- abnormal external carotid artery origin
- abnormal eye muscle morphology
- abnormal fertility/fecundity
- abnormal forebrain morphology
- abnormal hair cycle
- abnormal hair cycle anagen phase
- abnormal hair shedding
- abnormal humerus morphology
- abnormal hypoglossal nerve topology
- abnormal infrahyoid muscle connection
- abnormal joint morphology
- abnormal lens morphology
- abnormal liver physiology
- abnormal optic chiasm morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal rib morphology
- abnormal snout morphology
- abnormal spine curvature
- abnormal systemic artery morphology
- abnormal testis morphology
- abnormal thymus capsule morphology
- abnormal tooth morphology
- abnormal vertebral artery topology
- absent ductus venosus valve
- absent hypoglossal canal
- absent hypoglossal nerve
- absent segment of posterior cerebral artery
- absent stapedial artery
- alopecia
- basisphenoid bone foramen
- cataract
- decreased body length
- decreased body size
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating HDL cholesterol level
- decreased circulating LDL cholesterol level
- decreased circulating amylase level
- decreased circulating cholesterol level
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating glycerol level
- decreased energy expenditure
- decreased grip strength
- decreased lean body mass
- decreased length of long bones
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular volume
- decreased percent body fat/body weight
- decreased total body fat amount
- disheveled coat
- ductus venosus stenosis
- excessive tearing
- fusion of vertebral arches
- hyperactivity
- improved glucose tolerance
- increased carbon dioxide production
- increased energy expenditure
- increased erythrocyte cell number
- increased oxygen consumption
- intraembryonal intestine elongation
- kyphosis
- lethality incomplete penetrance
- lordosis
- male infertility
- oligozoospermia
- persistent dorsal ophthalmic artery
- persistent trigeminal artery
- preweaning lethality incomplete penetrance
- reduced sympathetic cervical ganglion size
- retroesophageal right subclavian artery
- small superior cervical ganglion
- subcutaneous edema
- testis degeneration
- thin hypoglossal nerve
- thin motoric part of trigeminal nerve
- thoracoschisis
- trigeminal neuroma
role in cell
- expression in
- proliferation
- migration
- invasion by
- phosphorylation in
- translation in
- differentiation
- cisplatin sensitivity
- doxorubicin sensitivity
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- sister chromatids
- nucleoplasm
- nucleoli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsun2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spermatid development
- in utero embryonic development
- regulation of stem cell differentiation
- meiotic cell cycle checkpoint
- hair follicle maturation
- mRNA processing
- tRNA methylation
- regulation of mRNA export from nucleus
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- spindle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tRNA (cytosine-5-)-methyltransferase activity
- RNA binding
- tRNA binding