Nsun2 Gene Summary [Rat]
Predicted to enable mRNA (cytidine-5-)-methyltransferase activity; tRNA (cytidine-5-)-methyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including RNA processing; regulation of mRNA export from nucleus; and tRNA stabilization. Predicted to act upstream of or within hair follicle maturation and in utero embryonic development. Predicted to be located in several cellular components, including chromatoid body; extracellular exosome; and nucleolus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsun2 |
| Official Name | NOP2/Sun RNA methyltransferase 2 [Source:RGD Symbol;Acc:1311954] |
| Ensembl ID | ENSRNOG00000017254 |
| Bio databases IDs | |
| Aliases | NOP2/Sun RNA methyltransferase 2 |
| Synonyms | D13Wsu123e, MISU, MRT5, NOL1/NOP2/Sun domain family member 2, NOP2/Sun RNA methyltransferase 2, RGD1311954, SAKI, TRM4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nsun2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (cytosine-5-)-methyltransferase
- NOL1/NOP2/sun family putative RNA methylase
- 16S rRNA methyltransferase RsmB/F
- enzyme
- protein binding
- AdoMet_MTases
- mRNA methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- prostate cancer
- cancer
- Alzheimer disease
- recurrent cancer
- stomach and esophageal carcinoma
- esophageal carcinoma formation
- gastric epithelial cancer
- rectal adenocarcinoma
role in cell
- expression in
- proliferation
- migration
- invasion by
- phosphorylation in
- translation in
- differentiation
- cisplatin sensitivity
- doxorubicin sensitivity
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- sister chromatids
- nucleoplasm
- nucleoli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nsun2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spermatid development
- in utero embryonic development
- regulation of stem cell differentiation
- meiotic cell cycle checkpoint
- hair follicle maturation
- mRNA processing
- tRNA methylation
- regulation of mRNA export from nucleus
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- spindle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tRNA (cytosine-5-)-methyltransferase activity
- RNA binding
- tRNA binding