Dimt1 Gene Summary [Mouse]
Predicted to enable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity. Predicted to be involved in positive regulation of rRNA processing; rRNA methylation; and ribosomal small subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in telencephalon ventricular layer. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dimt1 |
| Official Name | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913504] |
| Ensembl ID | ENSMUSG00000021692 |
| Bio databases IDs | |
| Aliases | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) |
| Synonyms | 1500031M22Rik, AV111347, DIM1, DIM1 rRNA methyltransferase and ribosome maturation factor, DIMT1L, HSA9761, HUSSY5, RGD1311752 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dimt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribosomal RNA small subunit methyltransferase A
- rRNA (adenine-N6,N6-)-dimethyltransferase
- Ribosomal RNA adenine dimethylase
- enzyme
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- infection by HIV-1
role in cell
- expression in
- production in
- binding in
- synthesis in
- processing in
- hyperpolarization in
- hyperpolarization
- maximal oxygen consumption rate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dimt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- rRNA methylation
- positive regulation of rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
- rRNA (adenine-N6,N6-)-dimethyltransferase activity