Ero1a Gene Summary [Mouse]
This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | Ero1a |
| Official Name | endoplasmic reticulum oxidoreductase 1 alpha [Source:MGI Symbol;Acc:MGI:1354385] |
| Ensembl ID | ENSMUSG00000021831 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum oxidoreductase 1 alpha |
| Synonyms | endoplasmic reticulum oxidoreductase 1 alpha, endoplasmic reticulum oxidoreductase 1 α, ERO1-alpha, ERO1-L, ERO1LA, ERO1-L-alpha, ERO1-L-α, ERO1-α, Ui-m-bh2.3-anx-g-02-0-u.sl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ero1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- protein disulfide oxidoreductase
- enzyme
- protein binding
- Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- non-insulin-dependent diabetes mellitus
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lung adenocarcinoma formation
- asbestosis
role in cell
- proliferation
- differentiation
- expression in
- phosphorylation in
- generation in
- accumulation in
- depletion in
- oxidation in
- organization
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- Golgi lumen
- intracellular membrane-bounded organelle
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ero1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- response to temperature stimulus
- protein maturation by protein folding
- chaperone mediated protein folding requiring cofactor
- cell redox homeostasis
- protein folding
- brown fat cell differentiation
- response to oxidative stress
- endoplasmic reticulum unfolded protein response
- extracellular matrix organization
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- cellular response to hypoxia
- release of sequestered calcium ion into cytosol
- response to endoplasmic reticulum stress
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- endoplasmic reticulum lumen
- extracellular space
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein disulfide oxidoreductase activity
- protein binding
- oxidoreductase activity
- thiol oxidase activity