Trpm2

Enables ligand-gated calcium channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; cellular response to temperature stimulus; and dendritic cell chemotaxis. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpm2 gene, providing context for its role in the cell.