Hlx Gene Summary [Mouse]
Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hlx |
| Official Name | H2.0-like homeobox [Source:MGI Symbol;Acc:MGI:96109] |
| Ensembl ID | ENSMUSG00000039377 |
| Bio databases IDs | |
| Aliases | H2.0-like homeobox |
| Synonyms | H2.0-like homeobox, HB24, HLX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hlx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- colorectal cancer
- hypoplasia
- hydrops fetalis
- hypoalbuminemia
- severe acute respiratory syndrome
- herniation
- anemia
role in cell
- expression in
- proliferation
- migration
- morphology
- abnormal morphology
- adherence
- differentiation
- sprouting
- senescence
- lifespan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hlx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T-helper 2 cell differentiation
- organ growth
- positive regulation of T-helper 1 cell differentiation
- signal transduction
- positive regulation of organ growth
- embryonic digestive tract morphogenesis
- regulation of transcription from RNA polymerase II promoter
- T-helper 1 cell differentiation
- T-helper 2 cell differentiation
- enteric nervous system development
- epithelial cell proliferation
- liver development
- skeletal muscle tissue development
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity