Desi2 Gene Summary [Mouse]
Predicted to enable deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; muscle tissue; and spleen. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Desi2 |
| Official Name | desumoylating isopeptidase 2 [Source:MGI Symbol;Acc:MGI:1926075] |
| Ensembl ID | ENSMUSG00000026502 |
| Bio databases IDs | |
| Aliases | desumoylating isopeptidase 2 |
| Synonyms | 5830417C01Rik, C1orf121, CGI-146, DESI, DESI1, desumoylating isopeptidase 2, FAM152A, PNAS-4, PPPDE1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Desi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-specific protease
- PPPDE putative peptidase domain
- enzyme
- protein binding
- acyl-CoA hydrolase
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- colon carcinoma
- colon epithelial cancer
- lung cancer
role in cell
- expression in
- proliferation
- S phase
- apoptosis
- activation in
- breakage in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Desi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- palmitoyl-(protein) hydrolase activity
- long-chain acyl-CoA hydrolase activity