Rgcc Gene Summary [Mouse]
Predicted to enable R-SMAD binding activity; protein kinase activator activity; and protein kinase binding activity. Involved in fibroblast activation. Predicted to be located in centrosome; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; hindlimb interdigital region mesenchyme; liver; and male reproductive gland or organ. Orthologous to human RGCC (regulator of cell cycle). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgcc |
| Official Name | regulator of cell cycle [Source:MGI Symbol;Acc:MGI:1913464] |
| Ensembl ID | ENSMUSG00000022018 |
| Bio databases IDs | |
| Aliases | regulator of cell cycle |
| Synonyms | 1190002H23Rik, bA157L14.2, C13ORF15, FLJ37760, regulator of cell cycle, RGC-32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgcc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- SMAD binding
- protein kinase binding
- Response gene to complement 32 protein family
- protein kinase regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- multiple sclerosis
- hepatic steatosis
- endometriosis
- serous ovarian cancer
- serous ovarian adenocarcinoma
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- peripheral T-cell lymphoma
role in cell
- expression in
- phosphorylation in
- proliferation
- quantity
- assembly in
- migration
- activation
- response by
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgcc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of cell proliferation
- negative regulation of fibroblast growth factor production
- positive regulation of mitosis
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of extracellular matrix constituent secretion
- positive regulation of epithelial to mesenchymal transition
- complement activation
- positive regulation of collagen biosynthetic process
- positive regulation of endothelial cell apoptotic process
- cellular response to hypoxia
- positive regulation of DNA biosynthetic process
- negative regulation of blood vessel endothelial cell migration
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of G1/S transition of mitotic cell cycle
- negative regulation of exit from mitosis
- positive regulation of stress fiber assembly
- positive regulation of gene expression
- negative regulation of endothelial cell proliferation
- negative regulation of cytokine production
- positive regulation of cytokine production
- negative regulation of cell-cell adhesion mediated by cadherin
- fibroblast activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein kinase activator activity
- R-SMAD binding