RGCC Gene Summary [Human]
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RGCC |
| Official Name | regulator of cell cycle [Source:HGNC Symbol;Acc:HGNC:20369] |
| Ensembl ID | ENSG00000102760 |
| Bio databases IDs | |
| Aliases | regulator of cell cycle, response gene to complement 32 |
| Synonyms | 1190002H23Rik, bA157L14.2, C13ORF15, FLJ37760, regulator of cell cycle, RGC-32 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGCC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- SMAD binding
- protein kinase binding
- Response gene to complement 32 protein family
- protein kinase regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- multiple sclerosis
- hepatic steatosis
- endometriosis
- serous ovarian cancer
- serous ovarian adenocarcinoma
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- peripheral T-cell lymphoma
role in cell
- expression in
- phosphorylation in
- proliferation
- quantity
- assembly in
- migration
- activation
- response by
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGCC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of cell proliferation
- negative regulation of fibroblast growth factor production
- positive regulation of mitosis
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of extracellular matrix constituent secretion
- positive regulation of epithelial to mesenchymal transition
- complement activation
- positive regulation of collagen biosynthetic process
- positive regulation of endothelial cell apoptotic process
- cellular response to hypoxia
- positive regulation of DNA biosynthetic process
- negative regulation of blood vessel endothelial cell migration
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of G1/S transition of mitotic cell cycle
- negative regulation of exit from mitosis
- positive regulation of stress fiber assembly
- positive regulation of gene expression
- negative regulation of endothelial cell proliferation
- negative regulation of cytokine production
- positive regulation of cytokine production
- negative regulation of cell-cell adhesion mediated by cadherin
- fibroblast activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein kinase activator activity
- R-SMAD binding