Clec5a Gene Summary [Mouse]
Enables virus receptor activity. Involved in several processes, including innate immune response; osteoblast development; and positive regulation of cytokine production. Acts upstream of or within myeloid cell differentiation and negative regulation of myeloid cell apoptotic process. Located in cell surface. Orthologous to human CLEC5A (C-type lectin domain containing 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec5a |
| Official Name | C-type lectin domain family 5, member a [Source:MGI Symbol;Acc:MGI:1345151] |
| Ensembl ID | ENSMUSG00000029915 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 5, member a |
| Synonyms | CLECSF5, C-type lectin domain containing 5A, C-type lectin domain family 5, member a, LOC684510, Ly100, MDL, MDL-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- viral receptor
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- transmembrane domain
- Lectin C-type domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- septic shock
- rheumatoid arthritis
- arthritis
- colorectal cancer
- autoimmune inflammation
- sepsis
- colon adenocarcinoma
- colon epithelial cancer
- neuroinflammation
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- proliferation
- activation
- differentiation
- cellular infiltration
- recruitment
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- tertiary granule membrane
- specific granule membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cellular defense response
- negative regulation of myeloid cell apoptotic process
- signal transduction
- innate immune response
- negative regulation of apoptotic process
- myeloid cell differentiation
- osteoblast development
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- cytosol
- tertiary granule membrane
- plasma membrane
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- viral receptor activity
- carbohydrate binding