Ctnnd2 Gene Summary [Mouse]
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be a structural constituent of postsynaptic density. Acts upstream of or within learning; morphogenesis of a branching structure; and regulation of synaptic plasticity. Located in postsynaptic density. Is expressed in several structures, including central nervous system; future brain; lung; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in anxiety disorder; major depressive disorder; and schizophrenia. Orthologous to human CTNND2 (catenin delta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctnnd2 |
| Official Name | catenin (cadherin associated protein), delta 2 [Source:MGI Symbol;Acc:MGI:1195966] |
| Ensembl ID | ENSMUSG00000022240 |
| Bio databases IDs | |
| Aliases | catenin (cadherin associated protein), delta 2 |
| Synonyms | catenin delta 2, catenin δ 2, CATND2, delta-CATENIN, GT24, neurojugin, NPRAP, δ-CATENIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctnnd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-cadherin binding domain
- Armadillo/beta-catenin-like repeat
- beta-catenin binding
- Armadillo/beta-catenin-like repeats
- protein binding
- structural molecule
- PDZ binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- epithelial cancer
- corneal astigmatism
- drusen
- pelvic organ prolapse
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- hereditary disorder
- idiopathic scoliosis
- asthma
role in cell
- proliferation
- growth
- morphology
- formation
- adhesion
- invasion
- branching
- density
- organization
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell periphery
- apical compartment
- cell-cell contacts
- lateral plasma membrane
- synaptosomes
- synapse
- anchoring junction
- cellular protrusions
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctnnd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- synapse organization
- regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- cell adhesion
- dendritic spine morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- postsynaptic density
- adherens junction
- cytoplasm
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- beta-catenin binding