Cdkn2aip Gene Summary [Mouse]
Predicted to enable p53 binding activity. Predicted to be involved in several processes, including DNA damage response; regulation of cell growth; and regulation of protein stability. Located in nucleus. Is expressed in brain; olfactory epithelium; and spinal cord. Orthologous to human CDKN2AIP (CDKN2A interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn2aip |
| Official Name | CDKN2A interacting protein [Source:MGI Symbol;Acc:MGI:1918175] |
| Ensembl ID | ENSMUSG00000038069 |
| Bio databases IDs | |
| Aliases | CDKN2A interacting protein |
| Synonyms | 4921511I16Rik, CARF, CDKN2A interacting protein, RGD1305302 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkn2aip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- XRN-Two Binding Domain, XTBD
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
regulated by
- FDX1
- geldanamycin
- palmitic acid
role in cell
- replication in
- apoptosis
- growth
- expression in
- accumulation in
- premature senescence
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell cortex
- granular components
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkn2aip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- regulation of protein stability
- negative regulation of cell growth
- positive regulation of signal transduction
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- granular component
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- RNA binding