Atad2 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; salivary gland; and spleen. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atad2 |
| Official Name | ATPase family, AAA domain containing 2 [Source:MGI Symbol;Acc:MGI:1917722] |
| Ensembl ID | ENSMUSG00000022360 |
| Bio databases IDs | |
| Aliases | ATPase family, AAA domain containing 2 |
| Synonyms | 2610509G12RIK, ANCCA, ATPase family AAA domain containing 2, ATPase family, AAA domain containing 2, CT137, LOC105375737, PRO2000 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase family associated with various cellular activities (AAA)
- AAA ATPase domain
- walker type A motif
- enzyme
- protein binding
- Bromodomain
- AAA domain (Cdc48 subfamily)
- AAA+ lid domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- epithelial cancer
- liver cancer
- Alzheimer disease
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- hepatocellular carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- apoptosis
- proliferation
- dynamics
- dynamics in
- transformation
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- positive regulation of transcription, DNA-dependent
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- histone binding
- chromatin binding