ATAD2 Gene Summary [Human]
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ATAD2 |
| Official Name | ATPase family AAA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30123] |
| Ensembl ID | ENSG00000156802 |
| Bio databases IDs | |
| Aliases | ATPase family AAA domain containing 2, AAA nuclear coregulator cancer-associated protein |
| Synonyms | 2610509G12RIK, ANCCA, ATPase family AAA domain containing 2, ATPase family, AAA domain containing 2, CT137, LOC105375737, PRO2000 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATAD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase family associated with various cellular activities (AAA)
- AAA ATPase domain
- walker type A motif
- enzyme
- protein binding
- Bromodomain
- AAA domain (Cdc48 subfamily)
- AAA+ lid domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- epithelial cancer
- liver cancer
- Alzheimer disease
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- hepatocellular carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- apoptosis
- proliferation
- dynamics
- dynamics in
- transformation
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATAD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- positive regulation of transcription, DNA-dependent
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- histone binding
- chromatin binding