Smdt1 Gene Summary [Mouse]
Predicted to enable channel activator activity and protein-macromolecule adaptor activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Located in mitochondrion. Is expressed in nervous system; neural retina; orbito-sphenoid; and vibrissa. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smdt1 |
| Official Name | single-pass membrane protein with aspartate rich tail 1 [Source:MGI Symbol;Acc:MGI:1916279] |
| Ensembl ID | ENSMUSG00000022452 |
| Bio databases IDs | |
| Aliases | single-pass membrane protein with aspartate rich tail 1 |
| Synonyms | 1500032L24Rik, C22orf32, DDDD, EMRE, Essential MCU regulator, LOC687237, RGD1311310, single-pass membrane protein with aspartate-rich tail 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smdt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative mitochondrial precursor protein
- channel regulator
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smdt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial calcium ion homeostasis
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging