Gpr183 Gene Summary [Mouse]
Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and retina. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr183 |
| Official Name | G protein-coupled receptor 183 [Source:MGI Symbol;Acc:MGI:2442034] |
| Ensembl ID | ENSMUSG00000051212 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 183 |
| Synonyms | EBI2, G protein-coupled receptor 183, hEBI2, LOC686966 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr183 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- oxysterol binding
- Cholecystokinin A receptor, N-terminal
- CW/FxP motif
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- basic domain
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr183 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Alzheimer disease
- prostate cancer
- septic shock
- androgenic alopecia
- early missed abortion
- systemic lupus erythematosus
- sepsis
- aortic valve calcification
- adult T-cell leukemia/lymphoma
role in cell
- activation in
- expression in
- phosphorylation in
- migration
- proliferation
- differentiation
- chemotaxis
- motility
- guidance
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr183 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dendritic cell homeostasis
- G-protein coupled receptor signaling pathway
- adaptive immune response
- B cell activation involved in immune response
- osteoclast differentiation
- mature B cell differentiation involved in immune response
- immune response
- T cell chemotaxis
- humoral immune response
- dendritic cell chemotaxis
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of B cell proliferation
- leukocyte chemotaxis
- regulation of astrocyte chemotaxis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- oxysterol binding