Kcnip3 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding activity; and transcription cis-regulatory region binding activity. Involved in protein localization to plasma membrane; regulation of potassium ion transmembrane transport; and response to magnesium ion. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of transcription by RNA polymerase II; and sensory perception of pain. Located in cytosol and nucleus. Part of protein-DNA complex and voltage-gated potassium channel complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; retina layer; and spinal cord. Orthologous to human KCNIP3 (potassium voltage-gated channel interacting protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnip3 |
| Official Name | Kv channel interacting protein 3, calsenilin [Source:MGI Symbol;Acc:MGI:1929258] |
| Ensembl ID | ENSMUSG00000079056 |
| Bio databases IDs | |
| Aliases | Kv channel interacting protein 3, calsenilin |
| Synonyms | 4933407H12Rik, CSEN, DREAM, KCHIP3, Kv channel interacting protein 3, calsenilin, PBP, potassium voltage-gated channel interacting protein 3, rKChIP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnip3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- calcium-dependent protein binding
- palmitoylation site
- EF-hand, calcium binding motif
- transcription regulator
- nucleic acid binding
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- calcium binding loop
- protein binding
- magnesium ion binding
- sequence-specific DNA binding
- leucine-charged residue-rich domains
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- EF-hand domain
- double-stranded DNA binding
- EF hand
- protein homodimerization
- ion channel binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- acute myeloid leukemia
- pulmonary fibrosis
- pain
- Parkinson disease
- hypoalgesia
- inflammatory pain
- touch abnormality
- motor dysfunction or movement disorder
- preeclampsia
role in cell
- proliferation
- degradation in
- quantity
- apoptosis
- phosphorylation in
- expression in
- survival
- upregulation in
- molecular cleavage in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- neurites
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnip3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- potassium ion transmembrane transport
- signal transduction
- apoptotic process
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- voltage-gated potassium channel complex
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- potassium channel regulator activity
- potassium channel activity