Ptp4a2 Gene Summary [Mouse]
Enables enzyme inhibitor activity. Acts upstream of or within protein geranylgeranylation. Is active in cytosol. Is expressed in genitourinary system and heart. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptp4a2 |
| Official Name | protein tyrosine phosphatase 4a2 [Source:MGI Symbol;Acc:MGI:1277117] |
| Ensembl ID | ENSMUSG00000028788 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase 4a2 |
| Synonyms | HH13, HH7-2, HU-PP-1, OV-1, PRL-2, protein tyrosine phosphatase 4A2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptp4a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- CXC geranylgeranylation motif
- CAAX box
- protein-tyrosine-phoshatase
- enzyme inhibitor activity
- phosphatase
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Ptp4a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- mediastinal cancer
- hematologic cancer
- hematological neoplasia
- lymphomagenesis
- lymphoid cancer
- lymphatic neoplasia
- hypotrophy
- organismal death
phenotypes
- abnormal bone structure
- decreased body length
- decreased lean body mass
- decreased mean corpuscular volume
- increased total body fat amount
- preweaning lethality incomplete penetrance
- short tibia
- abnormal body length
- abnormal cauda epididymis morphology
- abnormal maternal decidual layer morphology
- abnormal seminiferous tubule morphology
- abnormal testis morphology
- abnormal tibia morphology
- decreased birth body size
- decreased birth weight
- decreased body weight
- decreased cell proliferation
- decreased fetal weight
- decreased placenta weight
- decreased placental labyrinth size
- decreased spleen weight
- decreased spongiotrophoblast size
- decreased testis weight
- decreased trophoblast glycogen cell number
- increased male germ cell apoptosis
- oligozoospermia
- postnatal growth retardation
- slow postnatal weight gain
- small seminiferous tubules
- small testis
- teratozoospermia
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- growth
- activation in
- production in
- survival
- invasion by
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptp4a2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- prenylated protein tyrosine phosphatase activity