Rnaseh1 Gene Summary [Mouse]
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in mouse. An alternately spliced transcript variant has been found which is a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | Rnaseh1 |
| Official Name | ribonuclease H1 [Source:MGI Symbol;Acc:MGI:1335073] |
| Ensembl ID | ENSMUSG00000020630 |
| Bio databases IDs | |
| Aliases | ribonuclease H1 |
| Synonyms | H1RNA, LOC100506014, PEOB2, ribonuclease H1, RNH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnaseh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- ribonuclease H
- nucleic acid binding
- ribonuclease
- enzyme
- protein binding
- Caulimovirus viroplasmin
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions type 2
- chromosomal instability
- preeclampsia
- Leigh syndrome
role in cell
- apoptosis
- function
- transcription in
- phosphorylation in
- colony formation
- abnormal morphology
- breakage
- progression
- breakage in
- progression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnaseh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication, removal of RNA primer
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleic acid binding
- ribonuclease H activity
- RNA binding
- protein binding
- ribonuclease activity