Angptl8 Gene Summary [Mouse]
Predicted to enable hormone activity. Involved in several processes, including fat cell differentiation; regulation of primary metabolic process; and triglyceride homeostasis. Acts upstream of or within cell maturation. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angptl8 |
| Official Name | angiopoietin-like 8 [Source:MGI Symbol;Acc:MGI:3643534] |
| Ensembl ID | ENSMUSG00000047822 |
| Bio databases IDs | |
| Aliases | angiopoietin-like 8 |
| Synonyms | angiopoietin-like 8, C19orf80, EG624219, Gm6484, LOC100361444, loc55908, PRO1185, PVPA599, RIFL, TD26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angptl8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Pathways
Biological processes and signaling networks where the Angptl8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- hepatic steatosis
- fibrosis
- heart disease
- hyperthermia
- hypertriglyceridemia
- cardiac hypertrophy
- abdominal aortic aneurysm
- hepatic fibrosis
role in cell
- apoptosis
- differentiation
- molecular cleavage in
- migration
- enlargement
- inhibition in
- maturation
- dissociation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angptl8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- type B pancreatic cell proliferation
- cellular lipid metabolic process
- positive regulation of protein processing
- regulation of lipoprotein metabolic process
- cell maturation
- fat cell differentiation
- triglyceride homeostasis
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity