Angptl4 Gene Summary [Mouse]
Enables enzyme inhibitor activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and triglyceride homeostasis. Acts upstream of or within negative regulation of endothelial cell apoptotic process. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; heart; hemolymphoid system gland; and integumental system. Orthologous to human ANGPTL4 (angiopoietin like 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angptl4 |
| Official Name | angiopoietin-like 4 [Source:MGI Symbol;Acc:MGI:1888999] |
| Ensembl ID | ENSMUSG00000002289 |
| Bio databases IDs | |
| Aliases | angiopoietin-like 4 |
| Synonyms | angiopoietin-like 4, ARP4, Bk89, Fasting Induced Adipose Factor, FIAF, HARP, HFARP, LOC362850, Ng27, NL2, PGAR, Pgarg, PP1158, TGQTL, UNQ171 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angptl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibrinogen-like domain
- enzyme inhibitor activity
- enzyme binding
- coiled-coil domain
- protein binding
- furin cleavage site
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- atherosclerosis
- metastasis
- neoplasia
- epileptic seizure
- coronary artery disease
- obesity
- myocardial infarction
- colorectal cancer
- heart disease
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- migration
- lipolysis in
- invasion by
- signaling in
- formation
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angptl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of lipoprotein lipase activity
- response to hypoxia
- angiogenesis
- negative regulation of apoptotic process
- lipid metabolic process
- endothelial cell apoptotic process
- negative regulation of endothelial cell apoptotic process
- triglyceride homeostasis
- protein unfolding
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- enzyme inhibitor activity