Apoa5 Gene Summary [Mouse]
Predicted to enable several functions, including cholesterol transfer activity; enzyme activator activity; and heparin binding activity. Involved in acylglycerol homeostasis. Acts upstream of or within triglyceride metabolic process and triglyceride-rich lipoprotein particle remodeling. Predicted to be located in extracellular space. Predicted to be part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in lung. Human ortholog(s) of this gene implicated in cerebral infarction; coronary artery disease; familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to human APOA5 (apolipoprotein A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apoa5 |
| Official Name | apolipoprotein A-V [Source:MGI Symbol;Acc:MGI:1913363] |
| Ensembl ID | ENSMUSG00000032079 |
| Bio databases IDs | |
| Aliases | apolipoprotein A-V |
| Synonyms | 1300007O05Rik, APOAV, apolipoprotein A5, apolipoprotein A-V, HTGS, RAP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apoa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- lipid binding
- binding protein
- enzyme binding
- protein binding
- low-density lipoprotein receptor binding
- receptor binding
- enzyme activator activity
- proline rich domain
- heparin binding
- Apolipoprotein A1/A4/E domain
- transporter
Pathways
Biological processes and signaling networks where the Apoa5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hypertriglyceridemia type I
- dyslipidemia
- coronary artery disease
- hyperlipoproteinemia type V
- metabolic syndrome X
- hypertriglyceridemia
- diabetes mellitus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- lipid droplets
- cytosol
- endoplasmic reticulum lumen
- early endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apoa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- triglyceride-rich lipoprotein particle remodeling
- cholesterol metabolic process
- triglyceride metabolic process
- lipoprotein metabolic process
- tissue regeneration
- cholesterol homeostasis
- acylglycerol homeostasis
- positive regulation of fatty acid biosynthetic process
- lipid transport
- positive regulation of very-low-density lipoprotein particle remodeling
- cholesterol efflux
- positive regulation of triglyceride catabolic process
- triglyceride catabolic process
- triglyceride homeostasis
- positive regulation of receptor-mediated endocytosis
- positive regulation of lipoprotein lipase activity
- phospholipid efflux
- positive regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- endoplasmic reticulum lumen
- extracellular space
- early endosome
- chylomicron
- high-density lipoprotein particle
- low-density lipoprotein particle
- late endosome
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- lipase binding
- lipoprotein lipase activator activity
- phosphatidylcholine-sterol O-acyltransferase activator activity
- lipase activator activity
- lipid binding
- heparin binding
- enzyme activator activity
- phospholipid binding
- low-density lipoprotein particle receptor binding
- protein binding
- lipoprotein particle receptor binding
- phosphatidylcholine binding
- enzyme binding